Preclinical assessment and randomized Phase I study of CT-P63, a broadly neutralizing antibody targeting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Article Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 비임상, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome Beta Blood caused clinically Concentration coronavirus COVID-19 creatine phosphokinase CT-P63 deaths declining Delta demonstrated detectable dose double-blind evaluated groups healthy volunteer Immunity in vitro in vivo Infection Infectious virus lung monoclonal monoclonal antibody morbidity and mortality mutated variant Neutralizing Neutralizing activity neutralizing antibody neutralizing antibody. omicron pandemic parallel-group participant peaked phase Placebo placebo-controlled Preclinical prevalent Prophylactic Randomized reduced respiratory tract Safe SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants of concern Serious Adverse Events significantly single ascending dose study drug TEAE titre Tolerability Transgenic mouse treated Treatment treatment-emergent adverse event vaccination variants variants of SARS-CoV-2 wild-type [DOI] 10.1080/22221751.2022.2117094 PMC 바로가기
Prevalence of peripheral neuropathy and myopathy in patients post-COVID-19 infectionArticle Published on 2022-11-012022-11-16 Journal: International journal of rheumatic diseases [Category] SARS, 치료기술, [키워드] acute respiratory syndrome addition affecting All participant asymptomatic patient both group caused clinical examination Clinical signs Complete complications control group controls COVID-19 COVID-19 infection Department Electrophysiology Epidemic evaluate feature Gender groups healthy volunteer history Hospitalization Infection involved laboratory measure life-threatening long-lasting multiple organs Myopathy nervous system Patient patients performed Peripheral Neuropathy post-COVID-19 patient Prevalence problem recent respiratory symptom risk factor Risk factors Risk factors. SARS-CoV-2 serum creatine phosphokinase significant difference symptomatic without symptom [DOI] 10.1111/1756-185X.14409 PMC 바로가기
Humoral immune response against BNT162b2 mRNA COVID-19 vaccine in patients with rheumatic disease undergoing immunosuppressive therapy: A Japanese monocentric studyArticle Published on 2022-10-212022-11-15 Journal: Medicine [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome addition Analysis analyzed Antibody titer attenuate Baricitinib BNT162b2 mRNA BNT162b2 mRNA vaccination BNT162b2 vaccine Combination controls coronavirus coronavirus disease COVID-19 COVID-19 vaccine disease domain dose Glucocorticoids healthy volunteer humoral immune response immunomodulatory Immunosuppressant immunosuppressants immunosuppressive immunosuppressive agent Immunosuppressive medication impair inhibitor inhibitors interleukin-17 interleukin-6 investigated Japanese Kagawa methotrexate much lower Necrosis of BNT162b2 Outpatient Patient patients treated reduced rheumatic disease SARS-CoV-2 SARS-CoV-2 spike protein second dose serum serum antibody significantly significantly lower Spike protein the patient therapeutic agent Treatment university Vaccine [DOI] 10.1097/MD.0000000000031288 PMC 바로가기
Glycyrrhizin through liquorice intake modulates ACE2 and HMGB1 levels-A pilot study in healthy individuals with implications for COVID-19 and ARDSArticle Published on 2022-10-172022-11-15 Journal: PLoS ONE [Category] 치료제, [키워드] ACE2 ACE2 expression acute respiratory distress alarmin Analysis angiotensin-converting enzyme 2 Antiviral ARDS ARDS patient baseline baseline levels blood sample cause cellular change collected coronavirus disease COVID-19 enrolled enzyme-linked immunosorbent exhibit expression glycyrrhizin healthy individual healthy volunteer HMGB1 hospitalised COVID-19 patient hospitalised patient immunomodulatory property implication in healthy individual in healthy individuals individual individuals liquorice material Mild modulate Non-COVID-19 not different Patient patients pilot study Plasma HMGB1 Potential treatment pro-inflammatory receptor ACE2 reduced reduction in Respiratory disease significantly significantly higher syndrome viral entry were measured with mild disease [DOI] 10.1371/journal.pone.0275181 PMC 바로가기
Heterologous adenovirus-vector/messenger RNA regimen is associated with improved severe acute respiratory syndrome coronavirus 2 humoral response in liver transplant recipientsArticle Published on 2022-10-012022-11-15 Journal: Hepatology communications [Category] COVID19(2023년), SARS, 진단, [키워드] 95% CI 95% confidence interval acute respiratory syndrome Analysis analyzed Anti-spike anti-Spike IgG Antibody Response AstraZeneca BBIBP-CorV BMI booster response ChAdOx1 Clinical data collected Combination Concentration Control coronavirus correlation different dose dose evaluate evaluated Future groups healthy volunteer Heterologous homologous humoral IgG immunized Immunoglobulin inactivated information liver LTR LTRs Messenger RNA MMF neutralizing antibody nucleocapsid protein Odds ratio positive positive serology Probability prospective cohort study R 2 receiving recipient reduced reduction regimen reported RNA SARS-CoV-2 SARS-CoV-2 anti-spike IgG Serious Adverse Event Side effects significant difference significantly significantly higher Sinopharm Vaccine vaccine dose vaccine platform [DOI] 10.1002/hep4.2034 PMC 바로가기
Seroepidemiological study of factors affecting anti-spike IgG antibody titers after a two-dose mRNA COVID-19 vaccination in 3744 healthy Japanese volunteersArticle Published on 2022-09-292022-11-15 Journal: Scientific Reports [Category] 진단, [키워드] 1.26 Adverse reaction affecting age anti-S anti-S antibody anti-S IgG anti-Spike IgG antibody Antibody titer Antibody titers BNT162b2 vaccine conducted COVID-19 vaccination cross-sectional dose Effect elapsed Factor Factors female females Gender healthy healthy volunteer identify IgG antibody titer immunosuppressants immunosuppressive IQR Japanese magnitude median age mRNA mRNA-1273 mRNA-1273 vaccine Multiple positive questionnaire SARS-COV-2 infection significantly smoking tested the vaccine therapy vaccination Vaccine Volunteer [DOI] 10.1038/s41598-022-20747-x PMC 바로가기
Increased percentage of apoptotic and CTLA-4 (CD152) expressing cells in CD4+/CD8+ cells in COVID-19 patientsArticle Published on 2022-09-232022-11-15 Journal: Medicine [Category] 바이오마커, 치료제, [키워드] addition analyzed Apoptosis apoptotic apoptotic cell association blood cell C-reactive protein can be used CD4+ cell CD8+ cell Cell cell count cells characterized Chest CT Clinical severity confirmed case correlated correlation COVID-19 COVID-19 case COVID-19 patient COVID-19 patients CRP CTLA-4 cytotoxic T-lymphocyte antigen-4 detect Diagnosis diagnostic Dyspnea eosinophil expressing expression ferritin flow cytometry healthy control healthy volunteer In-patients Increased Infectious disease lymphocyte Lymphocyte count lymphopenia neutrophil Patient patients Platelet proportion reduced severity significant difference significantly therapeutic targets Total up-regulated WBCs while white with COVID-19 [DOI] 10.1097/MD.0000000000030650 PMC 바로가기
Humoral and adaptive immune responses to the SARS-CoV-2 vaccineArticle Published on 2022-09-012022-11-15 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Activation Adaptive immune response Adaptive immunity adverse outcome B.1.1.7 B.1.617.2 Blood booster booster dose CD8+ Delta dose hallmark healthy volunteer high affinity humoral humoral immune response Humoral response IFN-γ immune response Infection memory mRNA vaccine neutralizing antibody nine omicron phenotype protective antibody response SARS-CoV-2 SARS-CoV-2 specific antibody SARS-CoV-2 spike antigen SARS-CoV-2 vaccines second vaccination sera Serum level subset T cell the SARS-CoV-2 vaccination Vaccine vaccine. Wuhan [DOI] 10.1016/j.ijid.2022.06.020 PMC 바로가기
Heterogenous CD8+ T Cell Maturation and ‘Polarization’ in Acute and Convalescent COVID-19 PatientsArticle Published on 2022-08-282022-11-15 Journal: Viruses [Category] SARS, 진단, 치료기술, 치료제, [키워드] acute COVID-19 acute phase adaptive analyzed antibody antiviral immune response CD3+CD8+ CD57 CD8+ CD8+ T cell CD8+ T cells Cell cells chemokine chemokine receptors collected convalescent correlated COVID-19 COVID-19 convalescent CXCR5 dendritic cells described detectable elevated expressed expressing expression flow cytometry Frequency healthy volunteer homing IgG antibody IL-27 immune response Interaction lung tissue majority memory memory CD8+ T cells Memory cells mucosal naïve Patient patient group patients Peripheral blood sample polarization post-COVID-19 syndrome. post-symptom onset SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein senescent serum subject subjects subset syndrome Tc1 Tc17 Tc2 TEMRA TEMRA cell Th1 cell tissue upregulated [DOI] 10.3390/v14091906 PMC 바로가기
A validated LC-MS/MS method for determination of antiviral prodrug molnupiravir in human plasma and its application for a pharmacokinetic modeling study in healthy Egyptian volunteers인간 혈장에서 항 바이러스 전구 약물 Molnupiravir의 결정을위한 검증 된 LC-MS/MS 방법 및 건강한 이집트 자원 봉사자들의 약동학 적 모델링 연구에 대한 적용Article Published on 2022-08-152022-08-31 Journal: Journal of chromatography. B, Analytical technolog [Category] COVID19(2023년), MERS, SARS, 치료기술, 치료제, [키워드] acetic acetic acid acetonitrile Agilent analyte analyzed Antiviral approach AUC C max Concentration confidence interval detection determine develop dosage dose Eclipse Efficacy ESI evaluate extraction FDA flow rate geometric mean geometric mean ratios Geometric means GMR Guidance healthy healthy volunteer healthy volunteers Human plasma LC-MS/MS Linear regression linearity m/z mass spectrometer mass spectrometry maximum concentration metabolite mixture molnupiravir N-hydroxycytidine NHC pharmacokinetic pharmacokinetic data plasma Population Population Pharmacokinetic Modeling positive protein precipitation pumped recommendation required ribavirin SARS-CoV-2 SARS-CoV-2. Simulation solvent subjects therapeutic target therapeutic targets Treatment triple quadrupole mass spectrometer United State United States Volunteer was performed was used were used [DOI] 10.1016/j.jchromb.2022.123363 PMC 바로가기 [Article Type] Article